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Point-of-use platforms seek to bring bioanalytical assays to the individual, thus enhancing the speed with which results are available to caregivers and empowering individuals to exert more control over their own health and wellness. Key challenges include: (a) adapting state-of-the-art bioassays, such as nucleic acid amplification and detection, microfluidic device design, and digital fluidics methods, so that they yield timely, point-of-use diagnoses, and (b) creating smart systems that can translate laboratory innovations into technically effective devices engineered to survive operation in the field. Additional hurdles to implementation may be posed by differing legal, regulatory, political, and social constraints imposed in the local environment.